To: Ralstonia pickettii bacteremia in hemodialysis patients: a report of two cases

I recently read the interesting report by Tejera et al. about Ralstonia pickettii, a gram-negative germ formerly of the Burkholderia group that infected two patients on hemodialyisis. The first was a 65-year-old man with a chronic kidney disease and native arteriovenous fistula who, and was managed in the intensive care unit (ICU) because of development of a septic shock. The transesophageal echocardiogram did not show vegetation, but cultures of blood and of dialysis fluid cultures revealed R. pickettii, which was controlled by with meropenem for two weeks. The second was a 45-year-old hemodiyalytic man with chronic rejection of a kidney transplant who was admitted to the ICU because of fever, chills and hypotension. The transthoracic echocardiogram showed a mitral vegetation. Moreover, the cultures of blood and of dialysis fluid cultures revealed R. pickettii, which was treated with piperacillin-tazobactam for three weeks. As discussed by the authors, this emerging opportunistic pathogen found in domestic and hospital water may cause severe bacteremia infections and septic shock related to health care. It is worth noting, that the gram-negative agents in venous catheters are a source of endocarditis. Persistent neutrophilic leukocytosis and spiked fever despite empirical antibiotic therapy should raise the hypothesis of endocarditis, and an echocardiogram can confirm the vegetation. The authors called attention to major issues about gram-negative endocarditis that can occur in healthcare-associated infections, especially in patients with catheters for hemodialysis. Gram-positive bacteria are the main cause of infectious endocarditis in hospitalized patients, but uncommon agents, such as Klebsiella, Salmonella and Burkholderia, have been described. In this setting, comments should be made about a Brazilian woman with a renal transplant and a diagnosis of endocarditis by Burkholderia cepacia associated with an intracardiac foreign body. This foreign body was a fragment of a peripherally inserted central catheter positioned 16 years earlier during her treatment in the ICU for a postpartum episode of septicemia and circulatory shock. The cardiac foreign body remained undetected until it was infected by the circulating bacteria, probably because of corticosteroids and muromonabe-Cd3 (OKT3) utilization after her renal transplant. The catheter fragment detected by imaging studies was removed by a cardiotomy procedure. The 40-year-old woman was treated with a combination of trimethoprim and sulfamethoxazole, considered the first option for her treatment in accordance with the antibiotic sensitivity test.